If you could, perhaps through signature rings or shims, have your scope adjustments perfectly centered at a given range, at what range would you center them if you intend to shoot at 100, 200 and 300 yards, as in some benchrest shoots?

Same question but for 1,000 yards.

Thanks, I am not really asking for specific come ups, I have those already.  It is hard to word this but I am talking about having your scope work at its best.  I think that would be when your elevation and windage turrets are at the middle of their range, and have maximum room for more adjustment.  So, if I have 300 clicks elevation, it would be 150 clicks.

 I cannot mount the scope to be centered at all distances but I can pick the optimal range.  If I will be shooting at targets at 100, 200 and 300 yards, I would think I want the turrets centered at 200, but I am not sure.

I may be picking nits on a gnats butt here.

I wouldn't want my scope vertical zero'ed at the perfect middle.  I'd want it at the beginning range of adjustment so that I'd have more room to travel.

I get what you're saying....I think........ if you have a scope with 100MOA of adjustment you'd want it zero'ed with exactly 50up and 50 down or adjustment at whatever distance you so desire (100, 200, etc)...... I'd rather have it offset..... with only 20 down and 80 up.....  that give me more room to stretch the legs so to speak.    The 20MOA bases and canted stuff helps get you this offset most desire....