I've not used a chronograph with it, but used it to go Axis hunting a few years ago. Devastating. KO was immediate... fell in place. I have fired it out to 500yds and it performs well out to that range. When I shot the Axis, (I still had all my data book information) I had actually zeroed with 140gr and had the tables for the 175gr (which had been previously verified at the range). I dialed the scope for the shot and POI was exactly where it was supposed to be.
It is a VERY effective round. I've not deer hunted with it, but just because I get "stuck" on certain rifles.